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WELCOME TO THE BRAVERMAN LABORATORY

In the Dx-PEX-Tx (Diagnosis, PEX genes, Treatment) laboratory, we are dedicated to studying peroxisome biology in health and diseases and finding therapies for peroxisomal disorders 

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TEAM MEMBERS

We are a small team of research professionals and students with a wide range of skills and experience dedicated to improving the lives of children, adolescents and adults with peroxisomal disorders.

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Nancy Braverman, MSc, MD, FACMG

Dr Braverman is a clinician-scientist, medical and biochemical geneticist, professor and teacher. 
She has been working in the field of peroxisome biogenesis disorders for more than two decades, and has seen the field grow spectacularly with hope of targeted therapies on the horizon. "Together we can do this!"

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Yeji Song

PhD Candidate

Yeji is a PhD candidate in Human Genetics at McGill, co-supervised by Dr. Heidi M. McBride and Dr. Nancy Braverman. She got her BSc in Physiology at McGill as well, where she did her undergraduate research on ependymal cells and their involvement in neuroinflammation under the supervision of Dr. Jo Anne Stratton at the Montréal Neurological Institute-Hospital. Motivated by her interest in pediatric health, Yeji has now shifted gears to studying a rare genetic disorder caused by hypomorphic variants in PEX16, in which patients exhibit an atypical, mild form of Zellweger Spectrum Disorder. In her spare time, Yeji likes to jog and explore new cafés. 

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Samy Omri, PhD

Research Associate

Samy is a Research Associate with 15 years of experience in the field of ocular pathologies with a particular interest in the outer retina and the subretinal changes. He is invested in the project supported by AmorChem Therapeutics dedicated to improving the understanding of vision loss associated with ZSD and developing a local gene strategy to restore it. When not in charge of science projects, Samy enjoys tennis and hiking.

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Wei Cui, PhD

Senior Research Technician

Wei is working on a RCDP mouse model and on CRISPR/Cas9 gene editing in patient cell lines. 

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Evelyn Zavacky

PhD Candidate

Evelyn is a PhD Candidate in the Department of Human Genetics at McGill. Before beginning her PhD, Evelyn worked as a clinical research coordinator in the Braverman Lab, where meeting families affected by peroxisomal disorders sparked her passion for rare disease research. Her current research focuses on developing antisense oligonucleotide (ASO) therapies for PEX6-mediated Zellweger spectrum disorder, with the goal of correcting allelic expression imbalance and restoring peroxisomal function. Outside the lab, Evelyn enjoys spending time with her senior tabby cat and unwinding with fibre arts, including crochet, knitting, and embroidery.

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Lingxiao Chen, PhD

Research Associate

Lingxiao's research focuses on characterizing the chronic liver disease in our PEX1-G844D mouse model, investigating the underlying disease mechanism, and testing the candidate drug therapies in our mice. When not in the lab, Lingxiao also loves cooking and trying out different recipes with her friends at home!

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Doris Hua

Clinical Research Coordinator, Natural History Study

Doris Hua graduated with a Bachelor of Science majoring in Biology and English. During her degree, she began to interweave her two interests and became entangled in the problem of communicating complex science to a wide variety of audiences! Today, she is busy honing this skill in her interactions with patients and their families in our natural history study. In her free time, you can catch her making art with her friends, crocheting, or on her radio show STEMinism on the local radio station CKUT 90.3FM. 

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Amrita Gosaine

PhD Candidate

Amrita is a PhD candidate in the Department of Human Genetics at McGill University. She completed her BSc in Anatomy and Cell Biology at McGill University. She developed a novel Pex16 deficient mouse model and is now characterizing it to better understand the brain pathophysiology of Zellweger Spectrum Disorder and to test potential CNS-directed therapies. Outside of the lab, Amrita enjoys watching movies.

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Erminia Di Pietro, PhD

Senior Research Technician

Erminia manages the daily functions of the lab and also is in charge of the LC-MSMS system where she performs biochemical analysis for peroxisome metabolites. When not in the lab, she enjoys spending time with her kids.

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Team members

ACHIEVEMENTS

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Poster and presentation awards

Congratulations to Mary Agopian who was awarded the first place for Best Junior Poster at the 7th Annual Child Health and Human Development Research Day 2021 at the MUHC-RI (November 2021). She presented her work on developing Machine-Learning Based Methodology for Severity Scoring of Mild and Intermediate PBD-ZSD.

 

Congratulations to Wedad Fallatah for her poster presentation entitled “Clinical, Biochemical and Molecular Phenotypes of Mild (Nonclassic) Rhizomelic Chondrodysplasia Punctata” to be one of the top-rated posters at the ACMG annual clinical genetics meeting, digital edition (May, 2020), TX, USA, and for her poster presentation entitled “Biochemical and Neurobehavioral Abnormalities in Pex7 Deficient Mouse, a Model for Rhizomelic Chondrodysplasia Punctata Type1 (RCDP1)” to win the 1st place presenter of the Kenneth Paigen, Ph.D Memorial Prize at the Annual human and Mammalian Genetics and Genomics: The McKusick Short Course (Virtual event, July, 2020). 

Congratulations to Catherine Argyriou who won the award for outstanding poster presentation at the 21st Annual American Society of Gene and Cell Therapy (ASGCT) meeting in Chicago Illinois in 2018.

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Congratulations to Catherine Argyriou for winning this prestigious fellowship from Mitacs (2020). This will allow her to participate in a research management training program while working with Dr. Braverman and venture capital fund AmorChem Therapeutics to advance gene therapy for PEX1-mediated Zellweger Spectrum Disorder (ZSD).

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Gillian Maclean Young Investigator Awards - Global Foundation for Peroxisomal Disorders

Congratulations to Catherine Argyriou (2017) and Christine Yergeau (2019) who received this award at the GFPD Family and Scientific Conference in Washington, DC. Their work and dedication to research in the field was recognized by the peroxisomal disorders community.

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2018 Pfizer Research Award of Excellence from the Montreal Children's Hospital Foundation

Congratulations to Nancy Braverman who was nominated by her peers at the Montreal Children's Hospital. Dr Braverman set herself apart by going above and beyond her job descriptions as well as her strong sense of collaboration across the various hospital departments. The notion of teamwork is at the heart of her success—an imperative feature that patients and families benefit from every single day.

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2017-2018 Research Faculty Teaching Award from the Department of Human Genetics at McGill University

Congratulations to Nancy Braverman who was nominated by her peers and her students in the Human Genetics Department at McGill University. Dr Braverman received this award in recognition of outstanding contributions in the teaching, supervision and mentorship of students.

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First prize at the 2017 Amorchem Knock-Out competition

Congratulations to Nancy Braverman and Catherine Argyriou for winning the first prize from venture capital seed fund AmorChem at the 2017 Knock-Out competition for the project “Retinal gene augmentation for peroxisome biogenesis disorders". “This treatment will improve the quality of life for people with PBD by improving their vision, one of the major handicaps for people living with this disorder.”, said Catherine. 

Click here to learn more. 

Achievements
CONTACT

CONTACT

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Our research lab is part of the

Child Health and Human Development (CHHD) research program

at the Research Institute of the McGill University Health Center

Please visit their websites for more information. 

Get In Touch

Contact Us

For any inquiries, questions, suggestions or if  you are interested in enrolling in our patient studies, please call us, send us an email or fill out the following form:

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Contact information

1001 Decarie blvd, Block E, #EM0.3211

Montreal, Quebec, Canada  H4A 3J1

 

pbd.genetics@mcgill.ca

Tel: 514-934-1934 ext 23403

Fax: 514-933-4149

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Donations

You can make donations to our research lab by visiting the Montreal Children's Foundation website

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Join our team

If you are interested in joining our lab, please contact us.

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A special thank you to Marie-Michèle Arpin - Graphiste who generously designed the DxPEXTx logo for our laboratory. Marie-Michèle is also a co-founder of PBD Canada.

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